Hydrochloric Acid → 4-(4-Chloro-2-fluoroanilino)-6-methoxy-7-(2-(1-methylimidazol-2-ylthio)ethoxy)quinazoline
Reaction equation
[C:34](=[O:35])([O-:36])[O-:37].[CH3:40][N:41]1[CH2:42][CH2:43][CH2:44][C:45]1=[O:46].[Cl:1][c:2]1[cH:3][c:4]([F:22])[c:5]([NH:6][c:7]2[n:8][cH:9][n:10][c:11]3[cH:12][c:13]([OH:19])[c:14]([O:17][CH3:18])[cH:15][c:16]23)[cH:20][cH:21]1.[Cl:24][CH2:25][CH2:26][S:27][c:28]1[n:29]([CH3:33])[cH:30][cH:31][n:32]1.[ClH:23].[K+:38].[K+:39].[OH2:47]>>[Cl:1][c:2]1[cH:3][c:4]([F:22])[c:5]([NH:6][c:7]2[n:8][cH:9][n:10][c:11]3[cH:12][c:13]([O:19][CH2:25][CH2:26][S:27][c:28]4[n:29]([CH3:33])[cH:30][cH:31][n:32]4)[c:14]([O:17][CH3:18])[cH:15][c:16]23)[cH:20][cH:21]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-f365a604e44244beb51e85525d9e90ff
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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