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HRID69959

反应详情

EQUATION

反应方程式

HRID 69959 的结构方程式

REACTANTS

反应物

4
结构：ClCCCl
HCID11

1,2-Dichloroethane

C2H4Cl2

结构：On1nnc2cccnc21
HCID181649

3H-1,2,3-Triazolo[4,5-b]pyridine, 3-hydroxy-

C5H4N4O

结构：Cc1nc(NC(=O)OC(C)(C)C)cc(-c2ccncc2N)n1
HCID69047460

未命名化合物

结构：Nc1cc(F)c(Br)nc1C(=O)O
HCID72698879

3-Amino-6-bromo-5-fluoro-2-pyridinecarboxylic acid

C6H4BrFN2O2

PRODUCTS

生成物

1
结构：Cc1nc(NC(=O)OC(C)(C)C)cc(-c2ccncc2NC(=O)c2nc(Br)c(F)cc2N)n1
HCID86669204

未命名化合物

收率 15%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Method 27 was followed using tert-butyl 6-(3-aminopyridin-4-yl)-2-methylpyrimidin-4-ylcarbamate (1.0 equiv.), 3-amino-6-bromo-5-fluoropicolinic acid (1.0 equiv.), EDC (1.0 equiv.), and HOAt (1.0 equiv.) in DMF yielding tert-butyl 6-(3-(3-amino-6-bromo-5-fluoropicolinamido)pyridin-4-yl)-2-methylpyrimidin-4-ylcarbamate in 15% yield. LCMS (m/z): 520.1 (MH+); LC Rt=3.4 min.