huagongshe.com
HRID69960

反应详情

EQUATION

反应方程式

HRID 69960 的结构方程式

REACTANTS

反应物

4
结构：ClCCCl
HCID11

1,2-Dichloroethane

C2H4Cl2

结构：On1nnc2cccnc21
HCID181649

3H-1,2,3-Triazolo[4,5-b]pyridine, 3-hydroxy-

C5H4N4O

结构：O=C(O)c1cccc(Br)n1
HCID593919

6-Bromopicolinic acid

C6H4BrNO2

结构：CC(C)(C)OC(=O)Nc1cc(-c2ccncc2N)nc(C(F)(F)F)n1
HCID69047673

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)Nc1cc(-c2ccncc2NC(=O)c2cccc(Br)n2)nc(C(F)(F)F)n1
HCID86669205

未命名化合物

收率 95%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN1CCCC1=O
溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

PROCEDURE

实验过程

Method 27 was followed using tert-butyl 6-(3-aminopyridin-4-yl)-2-(trifluoromethyl)pyrimidin-4-ylcarbamate (1.0 equiv.), 6-bromopicolinic acid (1.0 equiv.), EDC (1.0 equiv.), and HOAt (1.0 equiv.) in NMP yielding tert-butyl 6-(3-(6-bromopicolinamido)pyridin-4-yl)-2-(trifluoromethyl)pyrimidin-4-ylcarbamate>95% yield. LCMS (m/z): 539/541 (MH+); LC Rt=3.97 min.