Tetrahydrofuran → 4-(4-Hydroxymethyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester
Reaction equation
[Al+3:25].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[s:15][cH:16][c:17]([C:19](=[O:20])[O:21][CH2:22][CH3:23])[n:18]2)[CH2:12][CH2:13]1.[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[H-:24].[H-:27].[H-:28].[H-:29].[Li+:26]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[s:15][cH:16][c:17]([CH2:19][OH:20])[n:18]2)[CH2:12][CH2:13]1Participants
6
Sources & evidence
- ORD record
- ord-18b365ded5c94eed8518b24faf007e85
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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