Pyridine → 2-(3-([7-(3-chloropropoxy)quinazolin-4-yl]amino}-1H-pyrazol-5-yl)-N-(2,3-difluorophenyl)acetamide
Reaction equation
[CH3:46][CH2:47][O:48][C:49](=[O:50])[CH3:51].[Cl:10][CH2:11][CH2:12][CH2:13][O:14][c:15]1[cH:16][cH:17][c:18]2[c:19]([NH:25][c:26]3[n:27][nH:28][c:29]([CH2:31][C:32](=[O:33])[OH:34])[cH:30]3)[n:20][cH:21][n:22][c:23]2[cH:24]1.[F:1][c:2]1[c:3]([NH2:4])[cH:5][cH:6][cH:7][c:8]1[F:9].[P:35]([Cl:36])([Cl:37])([Cl:38])=[O:39].[cH:40]1[cH:41][cH:42][n:43][cH:44][cH:45]1>>[F:1][c:2]1[c:3]([NH:4][C:32]([CH2:31][c:29]2[nH:28][n:27][c:26]([NH:25][c:19]3[c:18]4[cH:17][cH:16][c:15]([O:14][CH2:13][CH2:12][CH2:11][Cl:10])[cH:24][c:23]4[n:22][cH:21][n:20]3)[cH:30]2)=[O:33])[cH:5][cH:6][cH:7][c:8]1[F:9]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-4241ab7d2b8a48aaa6276fcc0df45f9c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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