Sodium ion → 1-Benzyl-4-hydroxymethyl-4-(1,2,4-triazol-1-yl) piperidine

HRID 700229Notes

Reaction equation

HRID 700229 reaction equation
[Al+3:25].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][C:11]([n:14]2[n:15][cH:16][n:17][cH:18]2)([C:19](=[O:20])[O:21][CH2:22][CH3:23])[CH2:12][CH2:13]1.[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[H-:24].[H-:27].[H-:28].[H-:29].[Li+:26].[Na+:32].[OH-:31].[OH2:30]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][C:11]([n:14]2[n:15][cH:16][n:17][cH:18]2)([CH2:19][OH:20])[CH2:12][CH2:13]1

Participants

9

Reactant 8

HCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 15663646Ethyl 1-benzyl-4-(1,2,4-triazol-1-yl)-piperidin-4-yl carboxylate

Product 1

HCID 156636471-Benzyl-4-hydroxymethyl-4-(1,2,4-triazol-1-yl) piperidine

Sources & evidence

ORD record
ord-353c2f944eca4bb1b7baabc5e4c1b046
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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