反应详情

温度

120 °C

4.00 g 2,4-dichloro-6,7-dihydro-thieno[3,2-d]pyrimidine are placed in 15 ml dimethylformamide, then first 4.50 ml diisopropylethylamine, then 2.50 ml 3-fluoro-aniline are added. The reaction mixture is stirred for 7 hours at 120° C., and after cooling evaporated down. The residue is extracted with dichloromethane and water, the organic phase is washed with saturated sodium chloride solution, dried and evaporated to dryness. The residue is purified by chromatography (NP_MPLC, Biotage cartridge (4*15 cm)). 2.60 g of the product are obtained as a powder.

1. temperatureafter cooling
2. customevaporated down
3. extractionThe residue is extracted with dichloromethane and water
4. washthe organic phase is washed with saturated sodium chloride solution
5. customdried
6. customevaporated to dryness
7. customThe residue is purified by chromatography (NP_MPLC, Biotage cartridge (4*15 cm))