反应详情

2-Amino-3-bromopyridine (1.0 g, 5.8 mmol) and potassium ethyl xanthate (2.22 g, 13.9 mmol) were heated to 130° C. in DMF (5 mL) overnight. After cooling to rt, the reaction mixture was diluted with 1 M aqueous HCl (30 mL) and stirred at rt for an additional 1 h. The resulting solid was collected by filtration, washed with water (2×), and air-dried. The material was suspended in CH2Cl2 (2 mL) and sulfuryl chloride (5 mL) was added. After 2 h, water (30 mL) was added to decompose the excess sulfuryl chloride. The reaction mixture was diluted with EtOAc (30 mL) and washed with water (2×) and brine. The EtOAc layer was discarded. The combined aqueous washes were brought to pH ˜12 with 1 N aqueous NaOH and were extracted with EtOAc (3×). The combined EtOAc extracts were dried over Na2SO4, filtered, and concentrated under reduced pressure. This gave 0.933 g (95%) of the title compound as a yellow solid. LC-MS: RT=5.81 min., [M+H]+=171.1.

1. filtrationThe resulting solid was collected by filtration
2. washwashed with water (2×)
3. customair-dried
4. additionsulfuryl chloride (5 mL) was added
5. waitAfter 2 h
6. additionwater (30 mL) was added
7. additionThe reaction mixture was diluted with EtOAc (30 mL)
8. washwashed with water (2×) and brine
9. extractionwere extracted with EtOAc (3×)
10. dry with materialThe combined EtOAc extracts were dried over Na2SO4
11. filtrationfiltered
12. concentrationconcentrated under reduced pressure