Dimethylformamide → 2-(4-Fluorophenyl)-5-(5-(1-(5-fluoropyrimidin-2-yl)cyclo-propylcarbamoyl)-4-methoxy-2-methylphenyl)-N-methylbenzofuran-3-carboxamide

HRID 702896Notes

Reaction equation

HRID 702896 reaction equation
[CH3:44][CH2:45][N:46]([CH2:47][CH3:48])[CH2:49][CH3:50].[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[o:9][c:10]3[c:11]([c:12]2[C:13]([NH:14][CH3:15])=[O:16])[cH:17][c:18](-[c:21]2[c:22]([CH3:32])[cH:23][c:24]([O:30][CH3:31])[c:25]([C:26](=[O:27])[OH:28])[cH:29]2)[cH:19][cH:20]3)[cH:6][cH:7]1.[F:33][c:34]1[cH:35][n:36][c:37]([C:40]2([NH2:43])[CH2:41][CH2:42]2)[n:38][cH:39]1.[O:51]=[CH:52][N:53]([CH3:54])[CH3:55]>>[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[o:9][c:10]3[c:11]([c:12]2[C:13]([NH:14][CH3:15])=[O:16])[cH:17][c:18](-[c:21]2[c:22]([CH3:32])[cH:23][c:24]([O:30][CH3:31])[c:25]([C:26](=[O:27])[NH:43][C:40]4([c:37]5[n:36][cH:35][c:34]([F:33])[cH:39][n:38]5)[CH2:41][CH2:42]4)[cH:29]2)[cH:19][cH:20]3)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 592756045-(2-(4-Fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl)-2-methoxy-4-methylbenzoic acidHCID 672913621-(5-Fluoropyrimidin-2-yl)cyclopropanamine

Product 1

HCID 595051352-(4-Fluorophenyl)-5-(5-(1-(5-fluoropyrimidin-2-yl)cyclo-propylcarbamoyl)-4-methoxy-2-methylphenyl)-N-methylbenzofuran-3-carboxamide

Sources & evidence

ORD record
ord-5fbcb44ae4af4fb3984734e27458a843
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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