Hydrochloric Acid → HCID 10243410, compound

HRID 703125Notes

Reaction equation

HRID 703125 reaction equation
[CH3:1][NH:2][C:3](=[S:18])[NH:4][NH:5][C:6]([C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=1)=O.C([O-])(O)=O.[Na+].Cl>>[CH3:1][N:2]1[C:6]([C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=2)=[N:5][NH:4][C:3]1=[S:18]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 10083909HCID 10083909, compound

Product 1

HCID 10243410HCID 10243410, compound

Procedure

4-Methyl-1-(2-naphthoyl)thiosemicarbazide (12.9 g, 4.97×10-2 mole) and 1 molar aqueous NaHCO3 (480 ml, 4.80 ×10-1 mole) were stirred and warmed to reflux After refluxing overnight, the reaction was cooled in an ice bath before being acidified by the dropwise addition of concentrated hydrochloric acid (40 ml, 4.8×10-1 mole). The resulting product was collected by filtration and dried by suction. Mp 223°-225° C.

Workup

  1. temperaturewarmed
  2. temperatureto reflux
  3. temperatureAfter refluxing overnight
  4. temperaturethe reaction was cooled in an ice bath
  5. filtrationThe resulting product was collected by filtration
  6. customdried by suction

Sources & evidence

ORD record
ord-ced66d7dfb4c409fac4fb8096c2df93c
Source dataset
uspto-grants-1991_01
Patent number
US04981863

Reaction notes

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