Lithium Hydroxide → HCID 15027385, compound

HRID 703218Notes

Reaction equation

HRID 703218 reaction equation
[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH:17]([CH3:20])[NH:18][OH:19].[C:21](Cl)(=[O:23])[CH3:22].C(N(CC)CC)C.[OH-].[Li+]>>[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH:17]([N:18]([OH:19])[C:21](=[O:23])[CH3:22])[CH3:20]

Participants

5

Reactant 4

HCID 3939Lithium HydroxideHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 54337140HCID 54337140, compound

Product 1

HCID 15027385HCID 15027385, compoundYield 45%

Procedure

2-[(2,6-Dichloro-3-methylphenyl)amino]-N-hydroxy-α-methylbenzenemethanamine (1.2 g, 3.8 mmol) is reacted with acetyl chloride (0.66 g, 8.5 mmol), triethylamine (1.2 g, 11.6 mmol), and lithium hydroxide (0.46 g, 19.3 mmol) according to the procedure of Example 48 to give N-[1-[2-[(2,6-dichloro-3-methylphenyl)amino]phenyl]ethyl]-N-hydroxyacetamide (0.6 g, 45% yield); mp 185°-187° C.

Sources & evidence

ORD record
ord-c824b9aa84b34bafb781f959d5f0de5a
Source dataset
uspto-grants-1991_01
Patent number
US04981865

Reaction notes

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