Lithium Hydroxide → HCID 9927844, compound

HRID 703219Notes

Reaction equation

HRID 703219 reaction equation
[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][NH:18][OH:19].[C:20](Cl)(=[O:22])[CH3:21].C(N(CC)CC)C.[OH-].[Li+]>>[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][N:18]([OH:19])[C:20](=[O:22])[CH3:21]

Participants

5

Reactant 4

HCID 3939Lithium HydroxideHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 54549905HCID 54549905, compound

Product 1

HCID 9927844HCID 9927844, compoundYield 43.4%

Procedure

2-[(2,6-Dichloro-3-methylphenyl)amino]-N-hydroxybenzenemethanamine (1.00 g, 3.4 mmol) is reacted with acetyl chloride (0.58 g, 7.4 mmol), triethylamine (1.0 g, 10.1 mmol), and lithium hydroxide (0.40 g, 16.8 mmol) according to the procedure of Example 48 to give 0.5 g (43% yield) of N-[[2-[(2,6-dichloro-3-methylphenyl)amino]phenyl]methyl]-N-hydroxyacetamide; mp 155°-156° C.

Sources & evidence

ORD record
ord-c47f57293fef4ab6816092a0af3f0636
Source dataset
uspto-grants-1991_01
Patent number
US04981865

Reaction notes

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