反应详情

To a solution of 0.60 g of 5'-O-acetyl-3'-O-benzyl-2'-deoxy-5-fluorouridine in 30 ml of dry dioxane were added 0.42 g of isophthaloyl chloride and 1.11 ml of triethylamine, and the mixture was refluxed for 2 hours. Then 0.60 g of 4-benzoyloxy-5-chloro-2(1H)-pyridone and 1.11 ml of triethyl amine were added and the resulting mixture was refluxed for 1 hour. The precipitate thus formed was filtered off, and the filtrate was concentrated. The residue was placed on a silica gel column and eluted with 40% ethyl acetate-benzene, giving 0.45 g of the title compound in a yield of 37%.

1. temperaturethe mixture was refluxed for 2 hours
2. temperaturethe resulting mixture was refluxed for 1 hour
3. customThe precipitate thus formed
4. filtrationwas filtered off
5. concentrationthe filtrate was concentrated
6. washeluted with 40% ethyl acetate-benzene