HRID703701

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID65578

Ethanedioyl dichloride

C2Cl2O2

HCID69297

N-Benzyl-N-hydroxy-1-phenylmethanamine

C14H15NO

结构：CC(C)(C)c1cc(CCC(=O)O)cc(C(C)(C)C)c1O

HCID88389

Fenozan

C17H26O3

PRODUCTS

生成物

结构：CC(C)(C)c1cc(CCC(=O)ON(Cc2ccccc2)Cc2ccccc2)cc(C(C)(C)C)c1O

HCID14875968

未命名化合物

收率 77%

PROCEDURE

实验过程

The procedure of Example II is followed using 3.17 g (25 mmol) of oxalyl chloride, 6.96 g (25 mmol) of 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoic acid, 5.33 g (25 mmol) of N,N-dibenzylhydroxylamine, and 2.53 g (25 mmol) of triethylamine. The residue is recrystallized from petroleum ether to give 9.06 g (77%) of a white solid: mp 93°-95.5° C.

WORKUP

后处理

customThe residue is recrystallized from petroleum ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9d42e7d7dd2648879b2eb137ee4e85b1
来源数据集: uspto-grants-1991_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04983770
来源说明: uspto-grants-1991_01

反应 SMILES

C(Cl)(=O)C(Cl)=O.[C:7]([C:11]1[CH:12]=[C:13]([CH2:22][CH2:23][C:24]([OH:26])=[O:25])[CH:14]=[C:15]([C:18]([CH3:21])([CH3:20])[CH3:19])[C:16]=1[OH:17])([CH3:10])([CH3:9])[CH3:8].[CH2:27]([N:34]([CH2:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)O)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.C(N(CC)CC)C>>[C:7]([C:11]1[CH:12]=[C:13]([CH:14]=[C:15]([C:18]([CH3:19])([CH3:20])[CH3:21])[C:16]=1[OH:17])[CH2:22][CH2:23][C:24]([O:26][N:34]([CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[CH2:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)=[O:25])([CH3:10])([CH3:8])[CH3:9]