反应详情

In 20 ml of dimethylformamide was suspended 0.8 g (content: 60%) of sodium hydride, and then 3 g of 2,4-imidazolidinedione was added to the suspension and the mixture was stirred at room temperature for 30 minutes. Then, 2.75 g of 9-chloroacetylamino-1,2,3,4-tetrahydroacridine (described in "Chem. listy, Vol. 51, p. 1906 (1957)") was added to the mixture and reaction was carried out by heating to 80° C. for 30 minutes. After cooling to 10° C., the mixture was poured into 100 ml of an aqueous solution containing 8 g of ammonium chloride. Precipitated crystals were collected by filtration, washed with water and dried. These crystals were recrystallized from methanol-chloroform to give 2.5 g of the title compound. Melting point: 302° to 304° C. (decomposed).

1. temperatureby heating to 80° C. for 30 minutes
2. temperatureAfter cooling to 10° C.
3. customPrecipitated crystals
4. filtrationwere collected by filtration
5. washwashed with water
6. customdried
7. customThese crystals were recrystallized from methanol-chloroform