Methyl chloroacetate → HCID 22669299, compound

HRID 703798Notes

Reaction equation

HRID 703798 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][CH:4]=1.Cl[CH2:13][C:14]([O:16][CH3:17])=[O:15].C(=O)(O)[O-].[Na+]>>[CH3:17][O:16][C:14](=[O:15])[CH2:13][NH:7][C:6]1[CH:8]=[CH:9][C:3]([C:2]([F:10])([F:11])[F:1])=[CH:4][CH:5]=1

Participants

4

Reactant 3

HCID 7295Methyl chloroacetateHCID 99644-(Trifluoromethyl)anilineHCID 516892Sodium Bicarbonate

Product 1

HCID 22669299HCID 22669299, compoundYield 59.2%

Procedure

4-Trifluoromethylaniline (5.84 g), methyl chloroacetate (13.1 g) and sodium bicarbonate (3 g) were treated according to the method of Intermediate 5. The product was purified by FCC eluting with System B (1:3) to give the title compound (5.00 g), t.l.c. (System B, 1:3) Rf 0.32.

Workup

  1. customThe product was purified by FCC
  2. washeluting with System B (1:3)

Sources & evidence

ORD record
ord-3f6bb2a4e37f4df091dc0aafc0ed1a21
Source dataset
uspto-grants-1991_01
Patent number
US04985427

Reaction notes

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