Hydrochloric Acid → HCID 20075032, compound

HRID 703844Notes

Reaction equation

HRID 703844 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[C:7]1[CH2:8][O:9][C:10]2[CH:16]=[CH:15][C:14]([O:17][C:18]([CH3:25])([CH3:24])[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:13][C:11]=2[CH:12]=1.[ClH:26].CCOCC>C(O)C>[ClH:26].[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[C:7]1[CH2:8][O:9][C:10]2[CH:16]=[CH:15][C:14]([O:17][C:18]([CH3:24])([CH3:25])[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:13][C:11]=2[CH:12]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 20075033HCID 20075033, compound

Product 1

HCID 20075032HCID 20075032, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2 g (5.3 mmol) of ethyl 2-[3-(1-methyl-1H-imidazol-2-yl)-2H-1-benzopyran-6-yl]oxy-2-methylpropanoate in 30 ml of absolute ethanol is treated with gaseous HCl for 15 min, with external cooling. The solution is treated, under vigorous stirring, with 100 ml of ether. The precipitate is filtered, washed with ether and dried under vacuum, giving 1.95 g of ethyl 2-[3-(1-methyl-1H-imidazol-2-yl)-2H-1-benzopyran-6-yl]oxy-2-methylpropanoate hydrochloride, m.p. 154°-156° C.

Workup

  1. filtrationThe precipitate is filtered
  2. washwashed with ether
  3. customdried under vacuum

Sources & evidence

ORD record
ord-0aeacb52119a4755bd7e9d4ab2c1acae
Source dataset
uspto-grants-1991_01
Patent number
US04985440

Reaction notes

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