Hydrochloric Acid → HCID 15617838, compound

HRID 703903Notes

Reaction equation

HRID 703903 reaction equation
[C:1]1(=[O:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[N:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH:18]=O)[CH:13]=1.CC(C)([O-])C.[K+].Cl.[OH-].[Na+]>C(O)(C)(C)C>[N:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[C:1]=2[OH:11])[CH:13]=1

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 103713-PyridinecarboxaldehydeHCID 107241-TetraloneHCID 14798Sodium HydroxideHCID 23665647Potassium tert-butoxide

Product 1

HCID 15617838HCID 15617838, compound

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

A solution of 1-tetralone (5.85 g, 0.040 mole) and pyridine-3-carboxaldehyde (4.28 g, 0.40 mol) in t-butanol (400 mL) was treated with potassium t-butoxide (8.98 g, 0.080 mol) and the resulting mixture heated at reflux for 16 hours. After cooling to room temperature, the solution was poured into stirred 1.0N hydrochloric acid, and the pH of the resulting mixture was adjusted to 7.0 with 10% aqueous sodium hydroxide.

Workup

  1. temperaturethe resulting mixture heated
  2. temperatureat reflux for 16 hours
  3. additionthe solution was poured

Sources & evidence

ORD record
ord-624e8d7cf62d4b12bceb839f38387f79
Source dataset
uspto-grants-1991_01
Patent number
US04985435

Reaction notes

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