反应详情

5.0- Grams of 3-fluoro-4-nitrophenol, 3.57 g of acetic anhydride, 0.72 g of platinum dioxide and 50 ml of ethyl acetate were added to a reactor, and the atmosphere in the reactor was replaced by a hydrogen stream with stirring. Stirring was then continued at room temperature for 6 hours while introducing a hydrogen gas. Thereafter, the reaction solution was filtered off, and the filtrate was washed with two 50-ml portions of a 5% aqueous sodium hydrogencarbonate solution, dried and concentrated. The residue was subjected to chromatography on silica gel to obtain 4.47 g of 4-acetylamino-3fluorophenol.

1. stirringStirring
2. filtrationThereafter, the reaction solution was filtered off
3. washthe filtrate was washed with two 50-ml portions of a 5% aqueous sodium hydrogencarbonate solution
4. customdried
5. concentrationconcentrated