Potassium Fluoride → HCID 22149754, compound

HRID 704112Notes

Reaction equation

HRID 704112 reaction equation
[Cl:1][C:2]1[CH:15]=[C:14](Cl)[C:13]([F:17])=[CH:12][C:3]=1[C:4]([O:6][CH2:7][C:8]([F:11])([F:10])[F:9])=[O:5].[F-:18].[K+]>>[Cl:1][C:2]1[CH:15]=[C:14]([F:18])[C:13]([F:17])=[CH:12][C:3]=1[C:4]([O:6][CH2:7][C:8]([F:11])([F:10])[F:9])=[O:5]

Participants

3

Reactant 2

HCID 522689Potassium FluorideHCID 22149753HCID 22149753, compound

Product 1

HCID 22149754HCID 22149754, compoundYield 87.2%

Procedure

Into a 1 l glass reactor equipped with a condenser, 291 g (1 mol) of 2,2,2-trifluoroethyl 2,4-dichloro-5-fluorobenzoate, 87 g (1.5 mol) of spray dried potassium fluoride and 500 g of sulforane were charged and reacted at 180° C. for 9 hours under vigorous stirring. After cooling, the inorganic salt was removed by filtration, and the filtrate was distilled under reduced pressure to obtain 239.4 g (yield: 87.2%) of 2,2,2-trifluoroethyl 2-chloro-4,5-difluorobenzoate.

Workup

  1. customInto a 1 l glass reactor equipped with a condenser
  2. customreacted at 180° C. for 9 hours under vigorous stirring
  3. temperatureAfter cooling
  4. customthe inorganic salt was removed by filtration
  5. distillationthe filtrate was distilled under reduced pressure

Sources & evidence

ORD record
ord-7c08598ec8cc46bf829abdc801b7748f
Source dataset
uspto-grants-1991_01
Patent number
US04985588

Reaction notes

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