Water → HCID 15729558, compound

HRID 704322Notes

Reaction equation

HRID 704322 reaction equation
F[C:2]1[N:7]=[C:6]([S:8](Cl)(=[O:10])=[O:9])[CH:5]=[CH:4][CH:3]=1.Cl.[O:13](N)[CH3:14].C([N:18]([CH2:21]C)CC)C.[OH2:23]>C(Cl)(Cl)Cl>[CH3:14][O:13][N:18]([CH3:21])[S:8]([C:6]1[CH:5]=[CH:4][CH:3]=[C:2]([O:23][S:8]([CH3:6])(=[O:10])=[O:9])[N:7]=1)(=[O:10])=[O:9]

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 521874O-Methylhydroxylamine hydrochlorideHCID 157295366-Fluoropyridine-2-sulfonyl chloride

Product 1

HCID 15729558HCID 15729558, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

A solution of 6-fluoropyridine-2-sulphonylchloride (1.96 g) and methoxylamine hydrochloride (1.96 g) in chloroform (40 cm3) was cooled to -78° C. under an atmosphere of nitrogen and a solution of triethylamine (2.03 g) in chloroform (10 cm3) was added with stirring. The reaction mixture was added to water and the product extracted into chloroform. The combined organic layers were dried over magnesium sulphate, filtered and evaporated to give the title product.

Workup

  1. extractionthe product extracted into chloroform
  2. dry with materialThe combined organic layers were dried over magnesium sulphate
  3. filtrationfiltered
  4. customevaporated

Sources & evidence

ORD record
ord-ac0c0438638f4a129843754e9c188ddc
Source dataset
uspto-grants-1991_01
Patent number
US04987141

Reaction notes

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