反应详情

A solution of 1.20 g of p-chloromethyl-(4-phenylbutoxy)benzene and 1.15 g of potassium phthalimide in 20 ml of N,N-dimethylformamide was stirred at 100° C. for 3 hours. The reaction mixture was diluted with ethyl acetate, and the dilution was washed with three portions of water and then with saturated aqueous solution of sodium chloride, and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the residual solid was recrystallized from ethyl acetate to give 1.85 g of N-[p-(4-phenylbutoxy)benzyl]phthalimide. Melting point 106°-107.5° C. ##STR32##

1. washthe dilution was washed with three portions of water
2. dry with materialwith saturated aqueous solution of sodium chloride, and dried over anhydrous magnesium sulfate
3. distillationThe solvent was distilled off under reduced pressure
4. customthe residual solid was recrystallized from ethyl acetate