Hydrochloric Acid → HCID 12423052, compound

HRID 704420Notes

Reaction equation

HRID 704420 reaction equation
[CH3:1][C:2]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:9])[CH:3]=[CH:4][C:5]([O:7][CH3:8])=[O:6].[Mg].Cl>CO>[CH3:9][C:2]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:1])[CH2:3][CH2:4][C:5]([O:7][CH3:8])=[O:6]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 5462224MagnesiumHCID 53886261HCID 53886261, compound

Product 1

HCID 12423052HCID 12423052, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of methyl 4-methyl-4-phenyl-2-pentenoate (0.3 g) in absolute methanol (10 ml) was added metallic magnesium ribbons (0.36 g) and the mixture was stirred at room temperature for 2 hours. To the reaction mixture was added 10% hydrochloric acid and then the mixture was extracted with ethyl acetate. The extract was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to yield 0.30 g of methyl 4-methyl-4-phenylpentanoate.

Workup

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe extract was washed with a saturated aqueous solution of sodium chloride
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-5628407a53ee4bf790bd63915de04b5d
Source dataset
uspto-grants-1991_01
Patent number
US04987132

Reaction notes

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