Hydrogen Bromide → HCID 20074353, compound

HRID 704456Notes

Reaction equation

HRID 704456 reaction equation
[BrH:1].[CH2:2]([N:9]1[CH2:17][C:16]2[C:11](=[CH:12][C:13]([O:20]C)=[C:14]([O:18]C)[CH:15]=2)[CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>>[BrH:1].[CH2:2]([N:9]1[CH2:10][C:11]2[C:16](=[CH:15][C:14]([OH:18])=[C:13]([OH:20])[CH:12]=2)[CH2:17]1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 149937372-Benzyl-5,6-dimethoxyisoindoline

Product 1

HCID 20074353HCID 20074353, compoundYield 96.5%

Procedure

3.54 ml of 48% hydrobromic acid was added to 500 mg (1.86 mmol) of 2-benzyl-5,6-dimethoxyisoindoline, and the mixture was refluxed for 3 hours under stirring. The precipitated crystals were collected from the reaction solution, and washed with water and acetone to obtain 578 mg (yield: 96.5%) of the above identified compound as colorless prism crystals.

Workup

  1. temperaturethe mixture was refluxed for 3 hours
  2. customThe precipitated crystals were collected from the reaction solution
  3. washwashed with water and acetone
  4. customto obtain 578 mg (yield: 96.5%) of the

Sources & evidence

ORD record
ord-302c4e8cd01d4e7bbab0ba0088e556fb
Source dataset
uspto-grants-1991_01
Patent number
US04987235

Reaction notes

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