反应详情

Pure potassium t-butoxide (50 mmoles, 5.61 g) is added portionwise to a stirred solution of 100 mmoles of hexanediol (11.82 gr) dissolved in 30 ml of THF at room temperature under argon. When addition is complete, 50 mmoles of benzylbromide (5.9 ml) are introduced and the reaction mixture is stirred at room temperature overnight. The white solid is then removed by filtration, the filtrate is evaporated and the residue is dissolved in ethylacetate, washed with saturated ammonium chloride, H2O and brine. Usual workup and purification by flash chromatography gives finally 7.51 g of product (72%).

1. additionWhen addition
2. customThe white solid is then removed by filtration
3. customthe filtrate is evaporated
4. dissolutionthe residue is dissolved in ethylacetate
5. washwashed with saturated ammonium chloride, H2O and brine
6. customUsual workup and purification by flash chromatography