反应详情

To a suspension of 1.542 g of 6-hydroxymethyl-3-(p- methoxybenzyl)oxy-4-pyridone in methanol is 5.710 g of allylamine at room temperature, and the mixture is stirred for 14 hours. After condensing at reduced pressure, 20 ml of ethyl acetate is added to the residue to perform crystallization. After the mixture is left standing at 4° C. for 4 hours, the crystal is collected by filtration, washed with a small amount of ethyl acetate and dried under reduced pressure to give 1.050 g of the title compound.

1. customat room temperature
2. additionis added to the residue
3. customcrystallization
4. waitAfter the mixture is left
5. waitstanding at 4° C. for 4 hours
6. filtrationthe crystal is collected by filtration
7. washwashed with a small amount of ethyl acetate
8. customdried under reduced pressure