Pyridine → HCID 86744552, compound

HRID 704808Notes

Reaction equation

HRID 704808 reaction equation
[O:1]([C:8]1[CH:9]=[C:10](/[CH:14]=[CH:15]/[C:16](=O)[CH3:17])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:20][OH:21].N1C=CC=CC=1>CO.CCOCC>[O:1]([C:8]1[CH:9]=[C:10](/[CH:14]=[CH:15]/[C:16](=[N:20][OH:21])[CH3:17])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 1049PyridineHCID 443297Hydroxyamine hydrochlorideHCID 15141037HCID 15141037, compound

Product 1

HCID 86744552HCID 86744552, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

The product from step (a) (10.0 g) and hydroxylamine hydrochloride (7 g) were taken up in methanol (50 ml), pyridine (15 ml) was added and the mixture stirred for 1 hour. The mixture was then stripped, redissolved in ether, washed with 2N aqu. HCl and satd. aqu. NaCl, dried over MgSO4, and stripped to give the desired product (10.2 g).

Workup

  1. washwashed with 2N aqu
  2. dry with materialNaCl, dried over MgSO4

Sources & evidence

ORD record
ord-bb73ea2d1b3140e1b69b2ac812073650
Source dataset
uspto-grants-1991_01
Patent number
US04988733

Reaction notes

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