N-(2,3-Epoxypropyl)phthalimide → HCID 13365967, compound

HRID 704875Notes

Reaction equation

HRID 704875 reaction equation
[O:1]1[CH2:15][CH:2]1[CH2:3][N:4]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]1=[O:14].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]=[N:25][C:26]([N:29]3[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]3)=[N:27][CH:28]=2)=[CH:19][CH:18]=1>C(O)(C)C>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]=[N:25][C:26]([N:29]3[CH2:34][CH2:33][N:32]([CH2:15][CH:2]([OH:1])[CH2:3][N:4]4[C:12](=[O:13])[C:11]5[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=5)[C:5]4=[O:14])[CH2:31][CH2:30]3)=[N:27][CH:28]=2)=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 21601N-(2,3-Epoxypropyl)phthalimideHCID 4061276HCID 4061276, compound

Product 1

HCID 13365967HCID 13365967, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

0.022 mol of 2-(2,3-epoxypropyl)isoindole-1,3(2H)dione, 0.02 mol of 1-(5-(4-chlorophenyl)-2-pyrimidinyl)piperazine and 70 ml of isopropanol are heated to boiling for 2 hours. The mixture is evaporated and the residue is purified by column chromatography on silica gel 60. After elution with methylene chloride/alcohol (96:4), the compound is stirred with alcohol and filtered off with suction.

Workup

  1. customThe mixture is evaporated
  2. customthe residue is purified by column chromatography on silica gel 60
  3. washAfter elution with methylene chloride/alcohol (96:4)
  4. filtrationfiltered off with suction

Sources & evidence

ORD record
ord-90bb8fb07ffd4f25b4cb974fde3177d1
Source dataset
uspto-grants-1991_01
Patent number
US04988809

Reaction notes

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