Piperazine → 5-Iodo-2-(piperazin-1-yl)pyrimidine

HRID 704880Notes

Reaction equation

HRID 704880 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([I:8])=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1>CN(C)C=O>[I:8][C:5]1[CH:4]=[N:3][C:2]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[N:7][CH:6]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 17142232-Chloro-5-iodopyrimidine

Product 1

HCID 157298765-Iodo-2-(piperazin-1-yl)pyrimidine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.02 mol of 2-chloro-5-iodopyrimidine, 0.06 mol of piperazine and 100 ml of absolute dimethylformamide are heated to 100o for 45 minutes and then evaporated. The crystalline residue is shaken with potassium bicarbonate solution and methylene chloride. The substance contained in the methylene chloride phase is purified by column chromatography over silica gel 60. The amine obtained by elution with methylene chloride/methanol (7:3) is stirred with isopropyl ether and filtered off with suction.

Workup

  1. customevaporated
  2. customis purified by column chromatography over silica gel 60

Sources & evidence

ORD record
ord-fd637f2b73fa4eada14437569a82efb3
Source dataset
uspto-grants-1991_01
Patent number
US04988809

Reaction notes

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