反应详情

温度

60 °C

0.01 mol of 2-(3-bromopropyl)-7-methoxy-1,2,4benzothiadiazin-3(4H)one 1,1-dioxide, 0.012 mol of 1-(2pyrimidinyl)piperazine and 0.01 mol of triethylamine are dissolved in 30 ml of DMF and the solution is heated at 60° C., with stirring, for 1.5 hours. Then 15 ml of water are added and the reaction mixture is cooled to 0° C. The substance which crystallises out during this is filtered off with suction, stirred with isopropanol, again filtered off with suction and dried in vacuo.

1. temperaturethe reaction mixture is cooled to 0° C
2. customThe substance which crystallises out during
3. filtrationthis is filtered off with suction
4. stirringstirred with isopropanol
5. filtrationagain filtered off with suction
6. customdried in vacuo