反应详情

N-{3-[3-(1,3-dioxolan-2-yl)phenoxy]propyl}-2-(furfurylsulfinyl)acetamide (20 g) was dissolved in 300 ml of acetone, and 60 ml of a 1N aqueous solution of HCl was added. The mixture was heated under reflux for 8 hours. After cooling, the solution was neutralized with a saturated aqueous solution of sodium hydrogen carbonate, concentrated and extracted with ethyl acetate. The organic layer was washed with water, and dried over anhydrous magnesium sulfate. The solvent was evaporated to give 17 g (yield 81%) of N-[3-(3-formylphenoxy)propyl]-2-(furfurylsulfinyl)acetamide.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 8 hours
3. temperatureAfter cooling
4. concentrationconcentrated
5. extractionextracted with ethyl acetate
6. washThe organic layer was washed with water
7. dry with materialdried over anhydrous magnesium sulfate
8. customThe solvent was evaporated