反应详情

Z-Glu-OBn (371 mg, 1 mmol) was dissolved in methylene chloride (1 mL), and CDI (180 mg, 1.1 mmol) was added thereto and stirred at room temperature for 30 minutes. Then, 2-amino-4-chlorophenol-6-sulfonic acid (223 mg, 1 mmol) and THF (1 mL) were added thereto and stirred overnight at room temperature. After removing a solvent, purification was conducted in accordance with the purification process A. The obtained intermediate was dissolved in a mixed solvent of methanol and water. Pd/C in catalyst quantity was added thereto and stirred under hydrogen atmosphere overnight at room temperature. After filtering out the catalyst and removing a solvent, purification was conducted in accordance with the purification process A to obtain a title compound.

1. stirringstirred overnight at room temperature
2. customAfter removing
3. customa solvent, purification
4. dissolutionThe obtained intermediate was dissolved in a mixed solvent of methanol and water
5. additionPd/C in catalyst quantity was added
6. stirringstirred under hydrogen atmosphere overnight at room temperature
7. filtrationAfter filtering out the catalyst
8. customremoving
9. customa solvent, purification