反应详情

Boc-Glu-OtBu (100 mg, 0.33 mmol) was dissolved in methylene chloride (1 mL) and THF (1 mL). CDI (65 mg, 1.1 mmol) was added thereto and stirred at room temperature for 30 minutes. Then, 5-amino-2-hydroxybenzene sulfonic acid salt (77 mg, 0.33 mmol) was added thereto and stirred overnight at room temperature. After removing a solvent, purification was conducted in accordance with the purification process A. The obtained intermediate was dissolved in 2 mL of TFA and stirred at room temperature for 3 hours, and a solvent was removed therefrom. The obtained product was purified in accordance with the purification process A to obtain a title compound.

1. stirringstirred overnight at room temperature
2. customAfter removing
3. customa solvent, purification
4. dissolutionThe obtained intermediate was dissolved in 2 mL of TFA
5. stirringstirred at room temperature for 3 hours
6. customa solvent was removed
7. customThe obtained product was purified in accordance with the purification process