反应详情

温度

120 °C

A mixture of 3-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)propanimidamide (150 mg, 0.316 mmol), K2CO3 (131 mg, 0.949 mmol) and methyl 2-formyl-3-(5-pyrim-idinyl)propanoate (188 mg, 0.633 mmol) in NMP (1.5 mL) was heated with a microwave reactor at 120° C. for 2 h. Purification via a reverse phase Biotage then afforded the title compound as a white solid. LCMS: rt=3.13 min, [M+H+]=487

1. customPurification via a reverse phase Biotage