Potassium Carbonate → HCID 178517736, compound

HRID 706001Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][C:17](=[NH:19])[NH2:18])=[CH:11][CH:10]=2)=[CH:4][C:3]=1[C:20]([F:23])([F:22])[F:21].C([O-])([O-])=O.[K+].[K+].[CH:30]([CH:32]([CH2:37][C:38]1[CH:39]=[N:40][CH:41]=[N:42][CH:43]=1)[C:33](OC)=O)=[O:31]>CN1C(=O)CCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:15][CH2:16][C:17]3[NH:18][CH:33]=[C:32]([CH2:37][C:38]4[CH:43]=[N:42][CH:41]=[N:40][CH:39]=4)[C:30](=[O:31])[N:19]=3)=[CH:13][CH:14]=2)=[CH:4][C:3]=1[C:20]([F:21])([F:22])[F:23]

Participants

Conditions

Temperature: 120 °C

Procedure

A mixture of 3-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)propanimidamide (150 mg, 0.316 mmol), K2CO3 (131 mg, 0.949 mmol) and methyl 2-formyl-3-(5-pyrim-idinyl)propanoate (188 mg, 0.633 mmol) in NMP (1.5 mL) was heated with a microwave reactor at 120° C. for 2 h. Purification via a reverse phase Biotage then afforded the title compound as a white solid. LCMS: rt=3.13 min, [M+H+]=487

Workup

customPurification via a reverse phase Biotage

Sources & evidence

ORD record: ord-ffd06e8f084a48278ec8a91b6288c607
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09174968B2

Reaction notes

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