Thioglycolic Acid → HCID 86652688, compound

HRID 706306Notes

Reaction equation

HRID 706306 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]=[CH:7][NH:8][C:4]=2[CH:3]=1.[F:11][C:12]1[CH:19]=[CH:18][C:15]([CH:16]=O)=[CH:14][CH:13]=1.[SH:20][CH2:21][C:22](O)=[O:23].N1CCCCC1>>[NH:8]1[C:4]2[CH:3]=[C:2]([N:1]3[C:22](=[O:23])[CH2:21][S:20][CH:16]3[C:15]3[CH:18]=[CH:19][C:12]([F:11])=[CH:13][CH:14]=3)[CH:10]=[CH:9][C:5]=2[N:6]=[CH:7]1

Participants

5

Reactant 4

HCID 1133Thioglycolic AcidHCID 8082PiperidineHCID 136235-AminobenzimidazoleHCID 680234-Fluorobenzaldehyde

Product 1

HCID 86652688HCID 86652688, compound

Procedure

The compound was synthesized starting from 5-aminobenzimidazole (0.133 g, 1.0 mmol), 4-fluoro-benzaldehyde (0.108 mL, 1.0 mmol), mercapto acetic acid (0.138 g, 1.5 mmol), piperidine, according to method 9 step A. yield: 69 mg (22%), MS m/z: 314.3 (M+H)+, HPLC [A]): rt 5.86 min (97%)

Workup

  1. customThe compound was synthesized
  2. customrt 5.86 min (97%)

Sources & evidence

ORD record
ord-1bdb65d433ce4dc5a661b5bdb3cd75d1
Source dataset
uspto-grants-2015_11
Patent number
US09173885B2

Reaction notes

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