Thioglycolic Acid → HCID 51030404, compound

HRID 706307Notes

Reaction equation

HRID 706307 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]=[CH:7][NH:8][C:4]=2[CH:3]=1.[SH:11][CH2:12][C:13]([OH:15])=O.N1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[NH:8]1[C:4]2[CH:3]=[C:2]([N:1]3[C:13](=[O:15])[CH2:12][S:11][CH:17]3[C:18]3[C:10]4[C:2](=[CH:3][CH:4]=[CH:5][CH:9]=4)[CH:21]=[CH:20][CH:19]=3)[CH:10]=[CH:9][C:5]=2[N:6]=[CH:7]1

Participants

4

Reactant 3

HCID 1133Thioglycolic AcidHCID 8082PiperidineHCID 136235-Aminobenzimidazole

Product 1

HCID 51030404HCID 51030404, compound

Procedure

The compound was synthesized starting from 5-aminobenzimidazole (0.133 g, 1.0 mmol), 4-naphthalen-1-yl carbaldehyde (0.157 mL, 1.0 mmol), mercapto acetic acid (0.157 g, 1.5 mmol), piperidine, according to method 9 step A yield: 54 mg (15.6%), MS m/z: 346.3 (M+H)+, HPLC [A]): rt 6.86 min (95%)

Workup

  1. customThe compound was synthesized
  2. customrt 6.86 min (95%)

Sources & evidence

ORD record
ord-21ef71a82b7d4034bbdf71e00841c5ab
Source dataset
uspto-grants-2015_11
Patent number
US09173885B2

Reaction notes

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