Thioglycolic Acid → HCID 51030405, compound

HRID 706308Notes

Reaction equation

HRID 706308 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]=[CH:7][NH:8][C:4]=2[CH:3]=1.[F:11][C:12]1[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[C:13]=1[CH:14]=O.[SH:21][CH2:22][C:23](O)=[O:24].N1CCCCC1>>[NH:8]1[C:4]2[CH:3]=[C:2]([N:1]3[C:23](=[O:24])[CH2:22][S:21][CH:14]3[C:13]3[C:12]([F:11])=[CH:19][CH:18]=[CH:17][C:16]=3[F:20])[CH:10]=[CH:9][C:5]=2[N:6]=[CH:7]1

Participants

5

Reactant 4

HCID 1133Thioglycolic AcidHCID 8082PiperidineHCID 136235-AminobenzimidazoleHCID 1362842,6-Difluorobenzaldehyde

Product 1

HCID 51030405HCID 51030405, compound

Procedure

The compound was synthesized starting from 5-aminobenzimidazole (0.133 g, 1.0 mmol), 2,6-difluoro-benzaldehyde (0.142 mg, 1.0 mmol), mercapto acetic acid (0.157 g, 1.5 mmol), piperidine, according to method 9 step A. yield: 208 mg (62.8%), MS m/z: 332.3 (M+H)+, HPLC [A]): rt 5.76 min (97%)

Workup

  1. customThe compound was synthesized
  2. customrt 5.76 min (97%)

Sources & evidence

ORD record
ord-f82e7378d7b047a9a91c6a28b555a6ab
Source dataset
uspto-grants-2015_11
Patent number
US09173885B2

Reaction notes

Loading…