反应详情

A mixture of ethyl 2-chloroacetate (220.8 g; 1802 mmol) and ethyl formate (133.5 g; 1802 mmol) was added slowly to a suspension of potassium t-butoxide (202.2 g; 1802 mmol) in diisopropyl ether (2000 mL) at 0° C. (maintaining the temperature <20° C.) with mechanical stirring. The mixture was stirred at ambient temperature for 24 hours. The solids were collected by filtration and washed with diisopropyl ether (500 mL) and acetonitrile (2×1500 mL). The material was dried under vacuum to give the product (270 g) which was used without further purification.

1. temperaturemaintaining the temperature <20° C.) with mechanical stirring
2. filtrationThe solids were collected by filtration
3. washwashed with diisopropyl ether (500 mL) and acetonitrile (2×1500 mL)
4. customThe material was dried under vacuum