HCID 86699326, compound → HCID 15050249, compound

HRID 706574Notes

Reaction equation

HRID 706574 reaction equation
[CH2:1]=[C:2]([C:4]1[CH:5]=[CH:6][C:7]([CH:10]=[O:11])=[N:8][CH:9]=1)[CH3:3].[H][H]>CO.[OH-].[OH-].[Pd+2]>[CH:2]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][OH:11])=[N:8][CH:9]=1)([CH3:3])[CH3:1]

Participants

5

Reactant 2

HCID 86699326HCID 86699326, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 15050249HCID 15050249, compoundYield 84%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

5-(prop-1-en-2-yl)picolinaldehyde (0.600 g, 4.08 mmol) was dissolved in methanol (15 mL). To this was added Pd(OH)2 (0.600 mgs, 20% catalyst on carbon, 50% water by weight) and the mixture was hydrogenated under a balloon of hydrogen for 2 hours. The mixture was then filtered through GF/F filter paper and the filtrate was concentrated under reduced pressure to give the title compound (84%).

Workup

  1. filtrationThe mixture was then filtered through GF/F
  2. filtrationfilter paper
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-5fca247aee1242bc8139b12a8059d713
Source dataset
uspto-grants-2015_11
Patent number
US09174981B2

Reaction notes

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