反应详情

3-Iodo-4-nitro-1H-indazole (0.38 g, 1.3 mmol) was reacted with K2CO3 (0.36 g, 2.6 mmol) in DMF (4 mL) for 15 minutes. 3-(Bromomethyl)-1-methylpyridin-2(1H)-one (0.28 g, 1.4 mmol) was added and the reaction mixture was stirred overnight. The reaction mixture was diluted with CH2Cl2 (30 mL), filtered and concentrated. The residue was partitioned between CHCl3 and saturated aqueous NaHCO3. The organic layer was dried over MgSO4 and concentrated. The residue was suspended in EtOAc (8 mL), stirred for 20 minutes and then filtered to provide 3-((3-iodo-4-nitro-1H-indazol-1-yl)methyl)-1-methylpyridin-2(1H)-one (0.27 g, 50% yield) as a solid.

1. filtrationfiltered
2. concentrationconcentrated
3. customThe residue was partitioned between CHCl3 and saturated aqueous NaHCO3
4. dry with materialThe organic layer was dried over MgSO4
5. concentrationconcentrated
6. stirringstirred for 20 minutes
7. filtrationfiltered