Triethylamine → HCID 178514733, compound

HRID 706863Notes

Reaction equation

HRID 706863 reaction equation
Cl.Cl.[O:3]1[CH2:8][CH2:7][N:6]([C@H:9]2[CH2:14][CH2:13][C@H:12]([NH2:15])[CH2:11][CH2:10]2)[CH2:5][CH2:4]1.F[C:17]1[CH:22]=[CH:21][C:20]([S:23]([NH2:26])(=[O:25])=[O:24])=[CH:19][C:18]=1[N+:27]([O-:29])=[O:28].C(N(CC)CC)C>O1CCCC1>[O:3]1[CH2:4][CH2:5][N:6]([C@H:9]2[CH2:10][CH2:11][C@H:12]([NH:15][C:17]3[CH:22]=[CH:21][C:20]([S:23]([NH2:26])(=[O:25])=[O:24])=[CH:19][C:18]=3[N+:27]([O-:29])=[O:28])[CH2:13][CH2:14]2)[CH2:7][CH2:8]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 167824874-Fluoro-3-nitrobenzenesulfonamideHCID 178478723HCID 178478723, compound

Product 1

HCID 178514733HCID 178514733, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of trans-4-morpholinocyclohexanamine dihydrochloride (5 g, 19.44 mmol), 4-fluoro-3-nitrobenzenesulfonamide (4.32 g, 19.63 mmol) and triethylamine (20 ml, 143 mmol) in tetrahydrofuran (60 ml) was stirred for 16 hours at room temperature. The solid product was filtered off, washed with tetrahydrofuran, ether, dichloromethane (3×) and dried under vacuum.

Workup

  1. filtrationThe solid product was filtered off
  2. washwashed with tetrahydrofuran, ether, dichloromethane (3×)
  3. customdried under vacuum

Sources & evidence

ORD record
ord-9f15e2f6e56747d2b6da934c470ee4b9
Source dataset
uspto-grants-2015_11
Patent number
US09174982B2

Reaction notes

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