Glycine methyl ester hydrochloride → HCID 44546614, compound

HRID 707146Notes

Reaction equation

HRID 707146 reaction equation
[CH:1]12[O:8][CH:5]([CH2:6][CH2:7]1)[CH2:4][N:3]([C:9]1[N:14]=[C:13]([N:15]3[CH2:20][CH2:19][C:18](=O)[CH2:17][CH2:16]3)[N:12]=[C:11]([C:22]3[CH:27]=[CH:26][C:25]([NH:28][C:29]([NH:31][C:32]4[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=4)=[O:30])=[CH:24][CH:23]=3)[N:10]=1)[CH2:2]2.C(O)(C(F)(F)F)=O.Cl.[CH3:46][O:47][C:48](=[O:51])[CH2:49][NH2:50]>C(N(CC)CC)C>[CH:1]12[O:8][CH:5]([CH2:6][CH2:7]1)[CH2:4][N:3]([C:9]1[N:10]=[C:11]([C:22]3[CH:23]=[CH:24][C:25]([NH:28][C:29]([NH:31][C:32]4[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=4)=[O:30])=[CH:26][CH:27]=3)[N:12]=[C:13]([N:15]3[CH2:16][CH2:17][CH:18]([NH:50][CH2:49][C:48]([O:47][CH3:46])=[O:51])[CH2:19][CH2:20]3)[N:14]=1)[CH2:2]2

Participants

4

Reactant 2

HCID 122755Glycine methyl ester hydrochlorideHCID 86636772HCID 86636772, compound

Product 1

HCID 44546614HCID 44546614, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineCatalyst

Procedure

Starting from 1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-(4-oxopiperidin-1-yl)-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-4-yl)urea-TFA (50 mg) and glycine methyl ester hydrochloride (20 mg) and triethylamine (10 drops) and following the procedure as outlined in example 118 the title compound was isolated as its di-TFA salt after HPLC purification; MS (ES+) 574.8 (M+H)+.

Sources & evidence

ORD record
ord-575729723f9a47a8ae5123f565b3b2c4
Source dataset
uspto-grants-2015_11
Patent number
US09174963B2

Reaction notes

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