Hydrochloric Acid → HCID 178478747, compound

HRID 707259Notes

Reaction equation

HRID 707259 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:11][C@@H:10]([NH:12][C:13]2[S:14][C:15]3[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=3[N:17]=2)[CH2:9]1)(C)(C)C.[ClH:23]>O1CCOCC1>[ClH:23].[ClH:23].[S:14]1[C:15]2[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=2[N:17]=[C:13]1[NH:12][C@H:10]1[CH2:9][C@@H:8]([NH2:7])[CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178454112HCID 178454112, compound

Product 1

HCID 178478747HCID 178478747, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of tert-butyl(cis-3-(benzo[d]thiazol-2-ylamino)cyclobutyl)carbamate (0.40 g, 1.252 mmol) in Dioxane (5 mL) was treated with hydrogen chloride, 4N in 1,4-dioxane (6.26 ml, 25.05 mmol). The resulting solution was stirred at room temperature for 2 h and concentrated to give the desired product cis —N1-(benzo[d]thiazol-2-yl)cyclobutane-1,3-diamine dihydrochloride (0.301 g, 1.030 mmol, 82% yield). 117243-44-1. The product was used in next step without further purification. m/z: 220.1 (M+1) (−2HCl)

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-c2135bdfbfc746418d181a50cd3d6425
Source dataset
uspto-grants-2015_11
Patent number
US09174992B2

Reaction notes

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