HCID 86694247, compound → HCID 86694248, compound

HRID 707387Notes

Reaction equation

HRID 707387 reaction equation
[Cl:1][C:2]1[C:7]([C:8]([OH:15])([CH3:14])[C:9]([O:11]CC)=[O:10])=[CH:6][CH:5]=[CH:4][N:3]=1>Cl>[Cl:1][C:2]1[C:7]([C:8]([OH:15])([CH3:14])[C:9]([OH:11])=[O:10])=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 1

HCID 86694247HCID 86694247, compound

Product 1

HCID 86694248HCID 86694248, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of ethyl 2-(2-chloropyridin-3-yl)-2-hydroxypropanoate (0.2 g, 0.871 mmol) in hydrochloric acid, 37% (Sigma Aldrich, 2.75 ml, 33.5 mmol) was heated in a sealed tube at 60° C. overnight. Reaction mixture was rotovapped and dried by vacuum pump. The residue containing 2-(2-chloropyridin-3-yl)-2-hydroxypropanoic acid was advanced to next step. M: 201.9.

Workup

  1. customReaction mixture
  2. customdried by vacuum pump
  3. additionThe residue containing 2-(2-chloropyridin-3-yl)-2-hydroxypropanoic acid

Sources & evidence

ORD record
ord-6b109b2737a146b38d5f7f8cacce5199
Source dataset
uspto-grants-2015_11
Patent number
US09174992B2

Reaction notes

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