Hydrochloric Acid → HCID 178426488, compound

HRID 707431Notes

Reaction equation

HRID 707431 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@@H:11]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][N:16]=2)[CH2:10][CH2:9]1)(C)(C)C.Cl.O1CCOCC1>>[CH3:21][C:18]1[CH:19]=[CH:20][C:15]([NH:14][C@H:11]2[CH2:12][CH2:13][C@@H:8]([NH2:7])[CH2:9][CH2:10]2)=[N:16][CH:17]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 178426494HCID 178426494, compound

Product 1

HCID 178426488HCID 178426488, compound

Procedure

To a round bottomed flask was added tert-butyl(cis-4-((5-methylpyridin-2-yl)amino)cyclohexyl)carbamate (0.2795 g, 0.915 mmol) and hydrogen chloride, 4.0M solution in 1,4-dioxane (1.144 ml, 4.58 mmol, Sigma-Aldrich Chemical Company, Inc.) to stir at room temperature for 6 h. Solvent was evaporated in vacuo to provide the title compound, which was carried on without further work up. LCMS showed product peak at 0.357 min (m+1=206.0).

Workup

  1. customSolvent was evaporated in vacuo

Sources & evidence

ORD record
ord-0e908e39c0584045837da2c29aaaeca2
Source dataset
uspto-grants-2015_11
Patent number
US09174992B2

Reaction notes

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