Potassium Carbonate → HCID 86705400, compound
Reaction equation
[CH3:1][C@H:2]1[CH2:7][N:6]([CH2:8][C:9]2[CH:18]=[N:17][C:16]3[NH:15][C:14](=[O:19])[N:13]4[N:20]=[CH:21][N:22]=[C:12]4[C:11]=3[CH:10]=2)[CH2:5][C@@H:4]([CH3:23])[O:3]1.[F:24][C:25]([F:36])([F:35])[O:26][C:27]1[CH:34]=[CH:33][C:30]([CH2:31]Br)=[CH:29][CH:28]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:1][C@H:2]1[CH2:7][N:6]([CH2:8][C:9]2[CH:18]=[N:17][C:16]3[N:15]([CH2:31][C:30]4[CH:33]=[CH:34][C:27]([O:26][C:25]([F:24])([F:35])[F:36])=[CH:28][CH:29]=4)[C:14](=[O:19])[N:13]4[N:20]=[CH:21][N:22]=[C:12]4[C:11]=3[CH:10]=2)[CH2:5][C@@H:4]([CH3:23])[O:3]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 55 °C
Procedure
To a mixture of 9-(((2S,6R)-2,6-dimethylmorpholino)methyl)pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one (50 mg, 0.16 mmol) and 4-(trifluoromethoxy)benzyl bromide (49 mg, 0.19 mmol) in N,N-dimethylformamide (2 ml) was added potassium carbonate (44 mg, 0.32 mmol). The resulting mixture was heated at 55° C. overnight. The crude mixture was filtered then purified directly via reverse phase HPLC to yield 273 (58 mg, 61%) as a white solid.
Workup
- filtrationThe crude mixture was filtered
- customthen purified directly via reverse phase HPLC
Sources & evidence
- ORD record
- ord-60fa8e74e35645338a311ad502415a23
- Source dataset
- uspto-grants-2015_11
- Patent number
- US09175010B2
Reaction notes
Loading…