Sodium Carbonate → HCID 86706842, compound

HRID 707649Notes

Reaction equation

HRID 707649 reaction equation
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]=O)=[CH:4][N:3]=1.Cl.[NH2:11][OH:12].C(=O)([O-])[O-].[Na+].[Na+]>CO>[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]=[N:11][OH:12])=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 31609702-Methylpyrimidine-5-carbaldehyde

Product 1

HCID 86706842HCID 86706842, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
30 °C

Procedure

To a mixture of 2-methyl-5-formyl-pyrimidine (180 gm) and hydroxylamine hydrochloride (128 gm) in 50% v/v aqueous methanol (3600 ml) was added sodium carbonate (94 gm). The reaction mixture was stirred at 30° C. for 0.5 h. The resulting suspension was cooled and filtered at −10° C. to provide single isomer of title compound in 113.5 gm quantity (56%) as a solid.

Workup

  1. temperatureThe resulting suspension was cooled
  2. filtrationfiltered at −10° C.

Sources & evidence

ORD record
ord-d89b366256aa4a3c95ceb7ad19240242
Source dataset
uspto-grants-2015_11
Patent number
US09175031B2

Reaction notes

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