反应详情

Toluene-4-thiosulfonic acid S-(3-chloro-propyl) ester (4.9 g, 18.4 mol, 1.00 eq.), N-methylpiperazine (1.9 g, 19.3 mmol) 1.05 eq.) and potassium carbonate (2.7 g, 19.4 mmol, 1.05 eq.) were stirred together in acetonitrile (100 mL) at room temperature for 64 hours. The mixture was concentrated and the residue was partitioned between ethyl acetate (500 ml) and water (250 ml). The organic solution was washed with water (2×200 mL), dried using MgSO4, concentrated and purified by MPLC to give a light yellow oil weighing 2.1 g (36%).

1. concentrationThe mixture was concentrated
2. customthe residue was partitioned between ethyl acetate (500 ml) and water (250 ml)
3. washThe organic solution was washed with water (2×200 mL)
4. customdried
5. concentrationconcentrated
6. custompurified by MPLC
7. customto give a light yellow oil