反应详情

20 g (64.3 mmol) of 1-iodo-2-ethyl-4-bromobenzene and 12 g (64.3 mmol) of 4-n-hexylphenylacetylene are initially introduced in 300 ml of triethylamine, 250 mg (1.3 mmol) of copper(I) iodide and 900 mg (1.3 mmol) of bis(triphenylphosphine)palladium(II) chloride are added, and the mixture is stirred at RT for 3 h and subsequently refluxed for 1 h. The batch is cooled, water and heptane are added, and the phases are separated. The organic phase is washed with saturated sodium chloride soln., dried over sodium sulfate, filtered and evaporated in a rotary evaporator. The residue is purified by column chromatography (SiO2, heptane); the product is obtained as a colourless oil.

1. temperaturesubsequently refluxed for 1 h
2. temperatureThe batch is cooled
3. customthe phases are separated
4. washThe organic phase is washed with saturated sodium chloride soln
5. dry with material, dried over sodium sulfate
6. filtrationfiltered
7. customevaporated in a rotary evaporator
8. customThe residue is purified by column chromatography (SiO2, heptane)
9. customthe product is obtained as a colourless oil