Propane sultone → HCID 89800278, compound
Reaction equation
[CH2:1]([NH2:4])[C:2]#[CH:3].[O:5]1[CH2:9][CH2:8][CH2:7][S:6]1(=[O:11])=[O:10]>C1COCC1>[CH2:1]([NH:4][CH2:9][CH2:8][CH2:7][S:6]([OH:11])(=[O:10])=[O:5])[C:2]#[CH:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
4 g (71.2 mmol) prop-2-yn-1-amine were dissolved in 75 ml THF and cooled to 0° C. To this mixture 8.87 g (71.2 mmol) 1,2-oxathiolane 2,2-dioxide dissolved in 25 ml THF were added drop wise at 0° to 5° C. After addition the reaction mixture was heated to room temperature and stirred for 12 hours.
Workup
- additionwere added drop wise at 0° to 5° C
- additionAfter addition the reaction mixture
- temperaturewas heated to room temperature
Sources & evidence
- ORD record
- ord-4db07e94a7af4af78f5f256a2bc1881c
- Source dataset
- uspto-grants-2015_11
- Patent number
- US09175399B2
Reaction notes
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